Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice-Reference-Cited by-同舟云学术

Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice

Published:2016-10-06 Issue:14 Volume:128 Page:1829-1833
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Saito Yasuyuki¹²^ORCID,Ellegast Jana M.¹,Rafiei Anahita¹,Song Yuanbin³,Kull Daniel⁴,Heikenwalder Mathias⁴⁵,Rongvaux Anthony³⁶,Halene Stephanie⁷⁸,Flavell Richard A.³⁹,Manz Markus G.¹

Affiliation:

1. Hematology, University Hospital and University of Zurich, Zurich, Switzerland;

2. Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan;

3. Department of Immunobiology, Yale University, New Haven, CT;

4. Institute of Virology, Technische Universität München, Helmholtz Zentrum München, Munich, Germany;

5. Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany;

6. Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA;

7. Section of Hematology, Department of Internal Medicine and

8. Yale Cancer Center, Yale University School of Medicine, New Haven, CT; and

9. Howard Hughes Medical Institute, Yale University, New Haven, CT

Abstract

Key Points Human cytokine knock-in mice are improved in vivo models for multilineage engraftment of mobilized PB CD34+ cells. Humanized mouse models might open new avenues for personalized studies of human pathophysiology of the hematopoietic and immune system.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/14/1829/1396067/1829.pdf

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4. Human-hemato-lymphoid-system mice: opportunities and challenges.;Manz;Immunity,2007

5. Advances in stem cell mobilization.;Hopman;Blood Rev,2014

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