Targetable genetic features of primary testicular and primary central nervous system lymphomas-Reference-Cited by-同舟云学术

Targetable genetic features of primary testicular and primary central nervous system lymphomas

Published:2016-02-18 Issue:7 Volume:127 Page:869-881
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chapuy Bjoern¹,Roemer Margaretha G. M.¹²,Stewart Chip³,Tan Yuxiang⁴,Abo Ryan P.⁵,Zhang Liye⁴,Dunford Andrew J.³,Meredith David M.⁶,Thorner Aaron R.⁵,Jordanova Ekaterina S.⁷,Liu Gang⁴,Feuerhake Friedrich⁸,Ducar Matthew D.⁵,Illerhaus Gerald⁹,Gusenleitner Daniel⁴,Linden Erica A.¹⁰,Sun Heather H.⁶,Homer Heather¹,Aono Miyuki¹,Pinkus Geraldine S.⁶,Ligon Azra H.⁶,Ligon Keith L.⁶,Ferry Judith A.¹¹,Freeman Gordon J.¹,van Hummelen Paul⁵,Golub Todd R.³¹²,Getz Gad³¹¹,Rodig Scott J.⁶,de Jong Daphne²,Monti Stefano⁴,Shipp Margaret A.¹

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

2. Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands;

3. Broad Institute, Cambridge, MA;

4. Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA;

5. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA;

6. Department of Pathology, Brigham and Women’s Hospital, Boston, MA;

7. Center of Gynaecologic Oncology, VU University Medical Center, Amsterdam, The Netherlands;

8. Department of Pathology, Hannover Medical School, Hannover, Germany;

9. Department of Hematology and Oncology, University Hospital Freiburg, Freiburg, Germany;

10. Massachusetts General Hospital/North Shore Cancer Center, Danvers, MA;

11. Department of Pathology, Massachusetts General Hospital, Boston, MA; and

12. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA

Abstract

Key Points PCNSLs and PTLs have a defining genetic signature that differs from other LBCLs and suggests rational targeted therapies. PCNSLs and PTLs frequently exhibit 9p24.1/PD-L1/PD-L2 copy number alterations and translocations, likely genetic bases of immune evasion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/7/869/1353834/869.pdf

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