A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum–infected erythrocytes-Reference-Cited by-同舟云学术

A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum–infected erythrocytes

Published:2016-01-21 Issue:3 Volume:127 Page:343-351
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Watermeyer Jean M.¹,Hale Victoria L.¹,Hackett Fiona²,Clare Daniel K.¹,Cutts Erin E.³,Vakonakis Ioannis³,Fleck Roland A.⁴,Blackman Michael J.²⁵,Saibil Helen R.¹

Affiliation:

1. Department of Biological Sciences, Birkbeck, University of London, London, United Kingdom;

2. The Francis Crick Institute, Mill Hill Laboratory, London, United Kingdom;

3. Department of Biochemistry, University of Oxford, Oxford, United Kingdom;

4. Centre for Ultrastructural Imaging, Kings College, London, United Kingdom; and

5. Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

Key PointsPlasmodium falciparum–generated cytoadherent knobs on infected erythrocytes contain a spiral framework linked to the red cell cytoskeleton. The findings suggest a structural basis for transmission of shear forces in adhesion of infected cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/3/343/1393735/343.pdf

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