von Willebrand factor multimerization and the polarity of secretory pathways in endothelial cells

Author:

Lopes da Silva Mafalda1ORCID,Cutler Daniel F.1ORCID

Affiliation:

1. Endothelial Cell Biology Laboratory, MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom

Abstract

Key Points The 3 endothelial secretory pathways—constitutive, basal, and regulated—release VWF in different multimeric states. Apical- and basolaterally-released VWF follow different secretory pathways, thus releasing differentially multimerized protein.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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5. Binding of von Willebrand factor to glycoproteins Ib and IIb/IIIa complex: affinity is related to multimeric size.;Federici;Br J Haematol,1989

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