A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma-Reference-Cited by-同舟云学术

A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma

Published:2016-06-23 Issue:25 Volume:127 Page:3202-3214
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Schieferdecker Aneta¹,Oberle Anna¹,Thiele Benjamin¹,Hofmann Fabian¹,Göthel Markus¹,Miethe Sebastian²³,Hust Michael²,Braig Friederike¹,Voigt Mareike¹,von Pein Ute-Marie⁴,Koch-Nolte Friedrich⁵,Haag Friedrich⁵,Alawi Malik⁶⁷,Indenbirken Daniela⁷,Grundhoff Adam⁷,Bokemeyer Carsten¹,Bacher Ulrike⁴⁸,Kröger Nicolaus⁴,Binder Mascha¹

Affiliation:

1. Department of Oncology and Hematology, Bone Marrow Transplantation with section Pneumology, Hubertus Wald Tumorzentrum/University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

2. Institut für Biochemie, Biotechnologie und Bioinformatik, Abteilung Biotechnologie, Technische Universität Braunschweig, Braunschweig, Germany;

3. YUMAB GmbH, Braunschweig, Germany;

4. Department of Stem Cell Transplantation,

5. Institute of Immunology, and

6. Bioinformatics Core, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

7. Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany; and

8. Department of Hematology and Oncology, Georg August University Göttingen, Göttingen, Germany

Abstract

Key Points The myeloma transplant B-cell immunome is predictive for response to treatment. It may be exploited by immunosequencing and library technology as a source for unique target structures and antibodies for immunotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/25/3202/1353498/3202.pdf

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