Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera

Author:

Casu Carla12ORCID,Oikonomidou Paraskevi Rea12,Chen Huiyong3,Nandi Vijay4,Ginzburg Yelena3,Prasad Princy5,Fleming Robert E.56,Shah Yatrik M.78,Valore Erika V.9,Nemeth Elizabeta9,Ganz Tomas910,MacDonald Brian11,Rivella Stefano121213

Affiliation:

1. Division of Hematology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA;

2. Division of Hematology-Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY;

3. Erythropoiesis Laboratory, and

4. Laboratory Data Analytic Services, New York Blood Center, New York, NY;

5. Department of Pediatrics, and

6. Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO;

7. Department of Molecular and Integrative Physiology, and

8. Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI;

9. Department of Medicine, and

10. Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA;

11. Merganser Biotech Inc., King of Prussia, PA;

12. Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY; and

13. Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA

Abstract

Key PointsInvestigation of the iron-restrictive effect of minihepcidin peptides in the treatment of β-thalassemia and polycythemia vera.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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