A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain-Reference-Cited by-同舟云学术

A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain

Published:2016-06-09 Issue:23 Volume:127 Page:2915-2923
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wong Szu S.¹²,Østergaard Søren²,Hall Gareth¹,Li Chan¹,Williams Philip M.¹,Stennicke Henning²,Emsley Jonas¹^ORCID

Affiliation:

1. Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom; and

2. Novo Nordisk, Måløv, Denmark

Abstract

Key Points A novel FXI binding tripeptide motif has sequence Asp-Phe-Pro (DFP). FXI complex crystal structures reveal DFP peptides bound to the apple 2 domain.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/23/2915/1394125/2915.pdf

Reference45 articles.

1. Factor XI and contact activation as targets for antithrombotic therapy.;Gailani;J Thromb Haemost,2015

2. Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII.;Bouma;J Biol Chem,1977

3. Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein.;Fujikawa;Biochemistry,1986

4. Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains.;McMullen;Biochemistry,1991

5. Crystal structure of the factor XI zymogen reveals a pathway for transactivation.;Papagrigoriou;Nat Struct Mol Biol,2006

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Biology of Factor Xl;Blood Journal;2023-10-24

2. Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites;Journal of Thrombosis and Haemostasis;2023-09

3. Structure of the Yeast Cell Wall Integrity Sensor Wsc1 Reveals an Essential Role of Surface-Exposed Aromatic Clusters;Journal of Fungi;2022-04-08

4. Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation;Journal of Medicinal Chemistry;2021-05-11

5. Design and synthesis of a multivalent catch-and-release assay to measure circulating FXIa;Thrombosis Research;2021-04