A von Willebrand factor fragment containing the D′D3 domains is sufficient to stabilize coagulation factor VIII in mice-Reference-Cited by-同舟云学术

A von Willebrand factor fragment containing the D′D3 domains is sufficient to stabilize coagulation factor VIII in mice

Published:2014-07-17 Issue:3 Volume:124 Page:445-452
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yee Andrew¹,Gildersleeve Robert D.¹,Gu Shufang²,Kretz Colin A.¹,McGee Beth M.¹,Carr Keisha M.¹,Pipe Steven W.²³,Ginsburg David¹²⁴⁵⁶

Affiliation:

1. Life Sciences Institute, University of Michigan,

2. Department of Pediatrics,

3. Department of Pathology,

4. Howard Hughes Medical Institute,

5. Department of Internal Medicine, and

6. Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI

Abstract

Key Points The D′D3 domains of VWF are sufficient to stabilize FVIII in vivo. The prolongation of VWF D′D3 survival in vivo by Fc fusion elevates FVIII levels in the setting of VWF but not FVIII deficiency.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/3/445/1465317/445.pdf

Reference55 articles.

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3. v. Willebrand’s disease in Sweden; its pathogenesis and treatment.;Nilsson;Acta Med Scand,1959

4. The hope and reality of long-acting hemophilia products.;Pipe;Am J Hematol,2012

5. Treatment of von Willebrand’s disease.;Mannucci;N Engl J Med,2004

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