Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model

Author:

Younan Patrick M.1,Polacino Patricia23,Kowalski John P.1,Peterson Christopher W.1,Maurice Nicholas J.1,Williams Nathaniel P.1,Ho On23,Trobridge Grant D.4,Von Laer Dorothee5,Prlic Martin1,Beard Brian C.1,DeRosa Stephen1,Hu Shiu-Lok23,Kiem Hans-Peter12

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. University of Washington, Seattle, WA;

3. Washington National Primate Research Center, Seattle, WA;

4. Washington State University, Pullman, WA; and

5. Innsbruck Medical University, Innsbruck, Austria

Abstract

Key Points Stem cell gene therapy results in enhanced virus-specific immunity and recovery of CD4+ T cells in a nonhuman primate model of AIDS. Gene therapy–mediated protection of stem cells results in a disease state similar to that observed in long-term nonprogressors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3