Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model-Reference-Cited by-同舟云学术

Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model

Published:2013-07-11 Issue:2 Volume:122 Page:179-187
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Younan Patrick M.¹,Polacino Patricia²³,Kowalski John P.¹,Peterson Christopher W.¹,Maurice Nicholas J.¹,Williams Nathaniel P.¹,Ho On²³,Trobridge Grant D.⁴,Von Laer Dorothee⁵,Prlic Martin¹,Beard Brian C.¹,DeRosa Stephen¹,Hu Shiu-Lok²³,Kiem Hans-Peter¹²

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. University of Washington, Seattle, WA;

3. Washington National Primate Research Center, Seattle, WA;

4. Washington State University, Pullman, WA; and

5. Innsbruck Medical University, Innsbruck, Austria

Abstract

Key Points Stem cell gene therapy results in enhanced virus-specific immunity and recovery of CD4+ T cells in a nonhuman primate model of AIDS. Gene therapy–mediated protection of stem cells results in a disease state similar to that observed in long-term nonprogressors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/2/179/1371296/179.pdf

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