Induction of B7-H6, a ligand for the natural killer cell–activating receptor NKp30, in inflammatory conditions

Author:

Matta Jessica123,Baratin Myriam123,Chiche Laurent45,Forel Jean-Marie5,Cognet Céline1236,Thomas Guillemette4,Farnarier Catherine6,Piperoglou Christelle6,Papazian Laurent5,Chaussabel Damien7,Ugolini Sophie123,Vély Frédéric1236,Vivier Eric1236

Affiliation:

1. Centre d’Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale, U1104, Marseille, France;

2. Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7280, Marseille, France;

3. Aix Marseille Université, UM2, Marseille, France;

4. Service de Médecine Interne, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France;

5. Réanimation-Détresses Respiratoires et Infections Sévères, Assistance Publique–Hôpitaux de Marseille, Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes CNRS-UMR 6236, Aix-Marseille Université, Marseille, France;

6. Service d’Immunologie, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France; and

7. Benaroya Research Institute, Seattle, WA

Abstract

Key Points B7-H6 transcripts, B7-H6 cell-surface expression, and sB7-H6 can be induced in inflammatory conditions in vitro and in vivo. B7-H6 is expressed on proinflammatory CD14+CD16+ monocytes in sepsis conditions and is linked to an increased mortality.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference52 articles.

1. Innate or adaptive immunity? The example of natural killer cells.;Vivier;Science,2011

2. Oncogenic stress sensed by the immune system: role of natural killer cell receptors.;Raulet;Nat Rev Immunol,2009

3. NK cell activating receptors and tumor recognition in humans.;Bottino;Curr Top Microbiol Immunol,2006

4. Surface NK receptors and their ligands on tumor cells.;Moretta;Semin Immunol,2006

5. Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44.;Byrd;PLoS ONE,2007

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