Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding-Reference-Cited by-同舟云学术

Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding

Published:2013-07-25 Issue:4 Volume:122 Page:523-532
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Verovskaya Evgenia¹,Broekhuis Mathilde J. C.¹,Zwart Erik¹,Ritsema Martha¹,van Os Ronald¹,de Haan Gerald¹,Bystrykh Leonid V.¹

Affiliation:

1. Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

Abstract

Key Points Quantitative clonal analysis demonstrates directional changes in contributions of stem cells to blood. The pool of aged hematopoietic stem cells is comprised of many, but small clones, while young stem cells are less numerous, but more potent.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/4/523/1372780/523.pdf

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