The impact of HLA unidirectional mismatches on the outcome of myeloablative hematopoietic stem cell transplantation with unrelated donors

Author:

Hurley Carolyn Katovich1,Woolfrey Ann2,Wang Tao3,Haagenson Michael4,Umejiego John4,Aljurf Mahmoud5,Askar Medhat6,Battiwalla Minoo7,Dehn Jason8,Horan John9,Oudshoorn Machteld10,Pidala Joseph11,Saber Wael12,Turner Victoria13,Lee Stephanie J.2,Spellman Stephen R.4

Affiliation:

1. Georgetown University, Washington, DC;

2. Fred Hutchinson Cancer Research Center, Seattle, WA;

3. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

4. Center for International Blood and Marrow Transplant Research, Minneapolis, MN;

5. King Faisal Specialist Hospital, Riyadh, Saudi Arabia;

6. Cleveland Clinic Lerner College of Medicine, Cleveland, OH;

7. Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;

8. National Marrow Donor Program, Minneapolis, MN;

9. Emory University, Atlanta, GA;

10. Europdonor Foundation and the Leiden University Medical Center, Leiden, The Netherlands;

11. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;

12. Medical College of Wisconsin, Milwaukee, WI; and

13. St. Jude Children’s Research Hospital, Memphis, TN

Abstract

Key Points Unidirectional graft-versus-host vector 7/8 HLA mismatches have the same level of risk as bidirectional 7/8 mismatches. For HLA homozygous recipients, a mismatch at the homozygous locus is preferred over a mismatch at the heterozygous loci.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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