Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells-Reference-Cited by-同舟云学术

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

Published:2016-09-22 Issue:12 Volume:128 Page:1651-1659
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Leclerc Mathieu¹²,Naserian Sina¹²,Pilon Caroline¹²³,Thiolat Allan¹²,Martin Gaëlle H.¹²,Pouchy Charlotte⁴,Dominique Claude⁵,Belkacemi Yazid¹⁵,Charlotte Frédéric⁶,Maury Sébastien¹²⁷,Salomon Benoit L.⁴,Cohen José L.¹²³

Affiliation:

1. Université Paris-Est, Unité mixte de recherche S955, Université Paris Est Créteil, Créteil, France;

2. INSERM, U955, Equipe 21, Créteil, France;

3. Assistance Publique Hôpitaux de Paris (APHP), Hôpital H. Mondor–A. Chenevier, Centre d’Investigation Clinique Biothérapie, Créteil, France;

4. Sorbonne Universités, UPMC Université Paris 06, INSERM, Centre Nationale de la Recherche Scientifique, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France;

5. APHP, Hôpital H. Mondor–A. Chenevier, Service d’oncologie-radiothérapie, Créteil, France;

6. APHP, Hôpital Pitié-Salpêtrière, Service d’anatomo-pathologie, Paris, France; and

7. APHP, Hôpital H. Mondor–A. Chenevier, Service d’hématologie clinique, Créteil, France

Abstract

Key Points In vivo Treg effect depends on TNFα produced by T cells. TNF/TNFR2 interaction represents a novel immune checkpoint therapy to modulate alloreactivity after allo-HCT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/12/1651/1396206/1651.pdf

Reference36 articles.

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2. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation.;Hoffmann;J Exp Med,2002

3. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality.;Taylor;Blood,2002

4. Immune reconstitution is preserved in hematopoietic stem cell transplantation coadministered with regulatory T cells for GVHD prevention.;Gaidot;Blood,2011

5. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation.;Edinger;Nat Med,2003

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