Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma-Reference-Cited by-同舟云学术

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma

Published:2017-01-05 Issue:1 Volume:129 Page:71-81
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Du Jing¹²,Neuenschwander Martin³,Yu Yong⁴,Däbritz J. Henry M.¹,Neuendorff Nina-Rosa¹,Schleich Kolja¹,Bittner Aitomi¹,Milanovic Maja¹,Beuster Gregor⁴,Radetzki Silke³,Specker Edgar³,Reimann Maurice¹,Rosenbauer Frank⁵,Mathas Stephan¹⁴,Lohneis Philipp⁶,Hummel Michael⁶⁷,Dörken Bernd¹⁴,von Kries Jens Peter³,Lee Soyoung¹⁴,Schmitt Clemens A.¹⁴⁷

Affiliation:

1. Medical Department of Hematology, Oncology, and Tumor Immunology, and Molekulares Krebsforschungszentrum, Charité - Universitätsmedizin Berlin, Berlin, Germany;

2. Center of Cancer Research, Binzhou Medical University Hospital, Binzhou, People’s Republic of China;

3. Screening Unit, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany;

4. Max-Delbrück-Center for Molecular Medicine, Helmholtz Association, Berlin, Germany;

5. Institute for Molecular Tumor Biology, Westfälische Wilhelms-Universität, Münster, Germany;

6. Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany; and

7. Berlin Institute of Health, Berlin, Germany

Abstract

Key Points A pharmacological screening identified compounds that reactivate B-cell–specific gene expression in cHL cell lines. B-cell phenotype-restoring drug combinations render cHL cell lines susceptible to B-NHL–reminiscent targeted therapies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/1/71/1398964/blood700773.pdf

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