Time-dependent changes in mortality and transformation risk in MDS

Author:

Pfeilstöcker Michael1,Tuechler Heinz2,Sanz Guillermo3,Schanz Julie4,Garcia-Manero Guillermo5,Solé Francesc6,Bennett John M.7,Bowen David8,Fenaux Pierre9,Dreyfus Francois10,Kantarjian Hagop5,Kuendgen Andrea11,Malcovati Luca12,Cazzola Mario12,Cermak Jaroslav13,Fonatsch Christa14,Le Beau Michelle M.15,Slovak Marilyn L.16,Levis Alessandro17,Luebbert Michael18,Maciejewski Jaroslaw19,Machherndl-Spandl Sigrid20,Magalhaes Silvia M. M.21,Miyazaki Yasushi22,Sekeres Mikkael A.19,Sperr Wolfgang R.23,Stauder Reinhard24,Tauro Sudhir25,Valent Peter26,Vallespi Teresa27,van de Loosdrecht Arjan A.28,Germing Ulrich11,Haase Detlef4,Greenberg Peter L.29

Affiliation:

1. Hanusch Hospital and L. Boltzmann Cluster Oncology, Vienna, Austria;

2. L. Boltzmann Institute for Leukemia Research, Vienna, Austria;

3. Hospital Universitario La Fe, Valencia, Spain;

4. Georg August Universität, Göttingen, Germany;

5. The University of Texas MD Anderson Cancer Center, Houston, TX;

6. Institut de Recerca contra la Leucèmia Josep Carreras, Barcelona, Spain;

7. James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY;

8. St James’s University Hospital, Leeds, United Kingdom;

9. Hopital Avicenne, Assistance Publique–Hopitaux de Paris (AP-HP)/University of Paris XIII, Bobigny, France;

10. Hopital Cochin, AP-HP, University of Paris V, Paris, France;

11. Heinrich-Heine University Hospital, Düsseldorf, Germany;

12. Fondazione Istituti di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo and University of Pavia, Pavia, Italy;

13. Institute of Hematology and Blood Transfusion, Praha, Czech Republic;

14. Medical University of Vienna, Vienna, Austria;

15. University of Chicago Comprehensive Cancer Research Center, Chicago, IL;

16. Department of Pathology, University of New Mexico, Albuquerque, NM;

17. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy;

18. University of Freiburg Medical Center, Freiburg, Germany;

19. Cleveland Clinic, Cleveland, OH;

20. Elisabethinen Hospital, Linz, Austria;

21. Federal University of Ceara, Fortaleza, Brazil;

22. Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;

23. Division of Hematology, Medical University of Vienna, Vienna, Austria;

24. University Hospital of Innsbruck, Innsbruck, Austria;

25. University of Dundee, Dundee, United Kingdom;

26. Division of Hematology, Medical University of Vienna and L. Boltzmann Cluster Oncology, Vienna, Austria;

27. Hospital Universitario Vall d’Hebron, Barcelona, Spain;

28. Vrije Universiteit Medical Center, Amsterdam, The Netherlands; and

29. Stanford Cancer Institute, Stanford, CA

Abstract

Key Points Hazards regarding mortality and leukemic transformation in MDS diminish over time in higher-risk but remain stable in lower-risk patients. This change of hazard indicates time-dependent attenuation of power of basal risk scores, which is relevant for clinical decision making.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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