Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis-Reference-Cited by-同舟云学术

Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis

Published:2016-07-21 Issue:3 Volume:128 Page:405-409
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kastritis Efstathios¹,Papassotiriou Ioannis²,Terpos Evangelos¹,Roussou Maria¹,Gavriatopoulou Maria¹,Komitopoulou Anna³,Skevaki Chrysanthi²,Eleutherakis-Papaiakovou Evangelos¹,Pamboucas Constantinos¹,Psimenou Erasmia¹,Manios Efstathios¹,Giannouli Stavroula⁴,Politou Marianna⁵,Gakiopoulou Harikleia⁶,Papadopoulou Elektra¹,Stamatelopoulos Kimon¹,Tasidou Anna⁷,Dimopoulos Meletios A.¹

Affiliation:

1. Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece;

2. Department of Clinical Biochemistry, and

3. Hemostasis Unit, Hemophilia Centre, Aghia Sophia Children's Hospital, Athens, Greece;

4. Second Department of Internal Medicine, National and Kapodistrian University of Athens School of Medicine, Athens, Greece;

5. Hematology Laboratory, Blood Bank, Aretaieion Hospital, Athens, Greece;

6. First Department of Pathology, National and Kapodistrian University of Athens School of Medicine, Athens, Greece; and

7. Department of Haemopathology, Evangelismos Hospital, Athens, Greece

Abstract

Key Points Serum levels of VWF antigen are elevated in AL amyloidosis, reflecting endothelial dysfunction. High VWF levels predict for poor outcome in patients with cardiac involvement and discriminate high-risk patients even within stage IIIB.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/3/405/1358839/405.pdf

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