Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD-Reference-Cited by-同舟云学术

Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD

Published:2016-03-10 Issue:10 Volume:127 Page:1361-1370
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Jacoby Elad¹,Yang Yinmeng¹,Qin Haiying¹,Chien Christopher D.¹,Kochenderfer James N.²,Fry Terry J.¹

Affiliation:

1. Pediatric Oncology Branch and

2. Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

Abstract

Key Points Donor-derived allogeneic CAR T cells are functional and eradicate ALL. Allogeneic CD4+ CAR T cells can mediate acute GVHD but only when CD19+ leukemia is present.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/10/1361/1392313/1361.pdf

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