Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation-Reference-Cited by-同舟云学术

Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation

Published:2016-05-12 Issue:19 Volume:127 Page:2298-2309
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mascarenhas Maria I.¹,Bacon Wendi A.¹,Kapeni Chrysa¹²,Fitch Simon R.¹,Kimber Gillian¹,Cheng S. W. Priscilla¹,Li Juan¹,Green Anthony R.¹,Ottersbach Katrin¹²^ORCID

Affiliation:

1. Department of Haematology, Cambridge Institute for Medical Research, Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; and

2. Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom

Abstract

Key Points Emerging HSCs require Jak2 and Pi3k signaling for proliferation and survival. Embryonic HSCs are unaffected by the JAK2V617F mutation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/19/2298/1393168/2298.pdf

Reference52 articles.

1. Developmental hematopoiesis: ontogeny, genetic programming and conservation.;Ciau-Uitz;Exp Hematol,2014

2. Concise review: From greenhouse to garden: the changing soil of the hematopoietic stem cell microenvironment during development.;Mirshekar-Syahkal;Stem Cells,2014