CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells-Reference-Cited by-同舟云学术

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells

Published:2016-07-21 Issue:3 Volume:128 Page:371-383
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sinclair Amy¹,Park Laura¹,Shah Mansi¹,Drotar Mark¹,Calaminus Simon²,Hopcroft Lisa E. M.¹,Kinstrie Ross¹,Guitart Amelie V.³,Dunn Karen¹,Abraham Sheela A.¹,Sansom Owen⁴,Michie Alison M.¹,Machesky Laura⁴,Kranc Kamil R.³,Graham Gerard J.⁵,Pellicano Francesca¹,Holyoake Tessa L.¹

Affiliation:

1. Paul O’Gorman Leukaemia Research Centre, College of Medical, Veterinary and Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom;

2. Centre for Cardiovascular and Metabolic Research, University of Hull, Hull, United Kingdom;

3. Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom;

4. Beatson Institute for Cancer Research, Glasgow, United Kingdom; and

5. Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Abstract

Key Points Chemokine ligands CXCL1-4, 6, 10, 11, and 13 are upregulated in human quiescent HSCs with CXCR2 and CXCL4 regulating their survival. Genetic ablation of Cxcr2 or Cxcl4 in murine models induces initial expansion but eventual exhaustion of HSC in transplantation assays.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/3/371/1359280/371.pdf

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