Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease-Reference-Cited by-同舟云学术

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

Published:2016-01-28 Issue:4 Volume:127 Page:473-486
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vinchi Francesca¹²³,Costa da Silva Milene¹²⁴⁵,Ingoglia Giada³,Petrillo Sara³,Brinkman Nathan⁶,Zuercher Adrian⁷,Cerwenka Adelheid⁵,Tolosano Emanuela³,Muckenthaler Martina U.¹²

Affiliation:

1. Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany;

2. Molecular Medicine Partnership Unit, Heidelberg University & European Molecular Biology Laboratory, Heidelberg, Germany;

3. Molecular Biotechnology Center & Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy;

4. Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal;

5. Innate Immunity Group, German Cancer Research Center, Heidelberg, Germany;

6. CSL Behring, Research & Development, Kankakee, IL; and

7. CSL Behring, Research & Development, Bern, Switzerland

Abstract

Key Points Heme and iron induce macrophage phenotypic switching toward an M1 proinflammatory phenotype. By scavenging free heme, hemopexin reverts heme-induced proinflammatory activation of macrophages in a mouse model of sickle cell disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/4/473/1395033/473.pdf

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4. Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development.;Schaer;Front Physiol,2014

5. Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.;Vinchi;Circulation,2013

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