Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance

Author:

Paiva Bruno1,Corchete Luis A.2,Vidriales Maria-Belen2,Puig Noemi2,Maiso Patricia1,Rodriguez Idoia1,Alignani Diego1,Burgos Leire1,Sanchez Maria-Luz3,Barcena Paloma3,Echeveste Maria-Asuncion4,Hernandez Miguel T.5,García-Sanz Ramón2,Ocio Enrique M.2,Oriol Albert6,Gironella Mercedes7,Palomera Luis8,De Arriba Felipe9,Gonzalez Yolanda10,Johnson Sarah K.11,Epstein Joshua11,Barlogie Bart11,Lahuerta Juan José12,Blade Joan13,Orfao Alberto3,Mateos María-Victoria2,San Miguel Jesús F.1

Affiliation:

1. Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain;

2. Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Centro de Investigación del Cancer, Salamanca, Spain;

3. Servicio General de Citometría, Centro de Investigación del Cancer, Instituto de Investigacion Biomedica de Salamanca and Department of Medicine, Universidad de Salamanca, Salamanca, Spain;

4. Hospital de Donostia, San Sebastian, Spain;

5. Hospital Universitario de Canarias, Tenerife, Spain;

6. Hospital Universitari Germans Trias i Pujol, Badalona, Spain;

7. Hospital Vall de Hebron, Barcelona, Spain;

8. Hospital Lozano Blesa, Zaragoza, Spain;

9. Hospital Morales Meseguer, Murcia, Spain;

10. Hospital Universitario Josep Trueta, Girona, Spain;

11. Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR;

12. Hospital 12 de Octubre, Madrid, Spain; and

13. Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain

Abstract

Key Points We report for the first time the biological features of MRD cells in MM and unravel that clonal selection is already present at the MRD stage. MRD cells show a singular phenotypic signature that may result from persisting clones with different genetic and gene expression profiles.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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