The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy-Reference-Cited by-同舟云学术

The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy

Published:2016-02-25 Issue:8 Volume:127 Page:989-996
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Jodele Sonata¹,Zhang Kejian²,Zou Fanggeng²,Laskin Benjamin³,Dandoy Christopher E.¹,Myers Kasiani C.¹,Lane Adam¹,Meller Jaroslav⁴⁵,Medvedovic Mario⁵,Chen Jenny⁵,Davies Stella M.¹

Affiliation:

1. Bone Marrow Transplantation and Immune Deficiency, and

2. Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH;

3. Division of Nephrology, The Children’s Hospital of Philadelphia, Philadelphia, PA;

4. Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; and

5. Department of Environmental Health, Division of Biostatistics and Bioinformatics, University of Cincinnati, Cincinnati, OH

Abstract

Key Points HSCT recipients with multiple complement gene variants (≥3) are at high risk for severe TA-TMA. Increased numbers of complement gene variants predisposing to TMA might contribute to racial disparities in transplant-related mortality.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/8/989/1395043/989.pdf

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