The IL-33/ST2 axis augments effector T-cell responses during acute GVHD-Reference-Cited by-同舟云学术

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

Published:2015-05-14 Issue:20 Volume:125 Page:3183-3192
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Reichenbach Dawn K.¹^ORCID,Schwarze Vincent²,Matta Benjamin M.³,Tkachev Victor⁴,Lieberknecht Elisabeth²,Liu Quan³,Koehn Brent H.¹,Pfeifer Dietmar²,Taylor Patricia A.¹,Prinz Gabriele²,Dierbach Heide²,Stickel Natalie²,Beck Yvonne²,Warncke Max⁵,Junt Tobias⁵,Schmitt-Graeff Annette⁶,Nakae Susumu⁷,Follo Marie²,Wertheimer Tobias²,Schwab Lukas²,Devlin Jason⁸,Watkins Simon C.⁸,Duyster Justus²,Ferrara James L. M.⁴,Turnquist Heth R.³⁹,Zeiser Robert²¹⁰,Blazar Bruce R.¹

Affiliation:

1. Department of Pediatrics, Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN;

2. Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Albert-Ludwigs-University of Freiburg, Freiburg, Germany;

3. Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA;

4. Department of Pediatrics, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI;

5. Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland;

6. Department of Pathology, University Medical Center Freiburg, Albert-Ludwigs-University of Freiburg, Freiburg, Germany;

7. Frontier Research Initiative, Institute of Medical Sciences, University of Tokyo, Tokyo, Japan;

8. Center for Biological Imaging and Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA;

9. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA; and

10. Centre for Biological Signaling Studies BIOSS, Albert-Ludwigs-University of Freiburg, Freiburg, Germany

Abstract

Key Points IL-33 and ST2 expression are increased post-conditioning and with GVHD, resulting in increased T-cell activation via the IL-33/ST2 axis. Infusion of ST2-Fc protein exploits sST2’s function as a negative regulator of acute GVHD inhibiting pro-inflammatory cytokines.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/20/3183/1386407/3183.pdf

Reference76 articles.

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3. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel ‘alarmin’?;Moussion;PLoS ONE,2008

4. The biological paths of IL-1 family members IL-18 and IL-33.;Smith;J Leukoc Biol,2011

5. IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.;Kurowska-Stolarska;J Immunol,2009

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