BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity-Reference-Cited by-同舟云学术

BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity

Published:2015-02-19 Issue:8 Volume:125 Page:1207-1216
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Pettirossi Valentina¹,Santi Alessia¹,Imperi Elisa¹,Russo Guido¹,Pucciarini Alessandra¹,Bigerna Barbara¹,Schiavoni Gianluca¹,Fortini Elisabetta¹,Spanhol-Rosseto Ariele¹,Sportoletti Paolo¹,Mannucci Roberta²,Martelli Maria Paola¹,Klein-Hitpass Ludger³,Falini Brunangelo¹,Tiacci Enrico¹

Affiliation:

1. Institute of Hematology, and

2. Institute of Internal Medicine and Oncologic Sciences, University of Perugia, Perugia, Italy; and

3. Biochip Laboratory, Institute for Cell Biology–Tumor Research, University of Duisburg-Essen, Essen, Germany

Abstract

Key Points The V600E kinase-activating mutation of BRAF profoundly shapes the distinct identity of HCL among B-cell neoplasms. Clinically available BRAF and MEK inhibitors exert potent antileukemic activity in patients’ HCL cells in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/8/1207/1387679/1207.pdf

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