Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling-Reference-Cited by-同舟云学术

Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling

Published:2015-06-18 Issue:25 Volume:125 Page:3917-3927
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Giambra Vincenzo¹,Jenkins Catherine E.¹,Lam Sonya H.¹,Hoofd Catherine¹,Belmonte Miriam¹,Wang Xuehai¹,Gusscott Sam¹,Gracias Deanne¹,Weng Andrew P.¹

Affiliation:

1. Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada

Abstract

Key Points A real-time, integrated fluorescent Wnt reporter marks rare leukemia stem cells in T-ALL. Deletion of β-catenin or Hif1α reduces LIC frequency in established tumors, but does not affect the growth of bulk cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/25/3917/1386993/3917.pdf

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