Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization-Reference-Cited by-同舟云学术

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization

Published:2015-05-07 Issue:19 Volume:125 Page:2995-3005
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kosoff Rachelle E.¹²,Aslan Joseph E.³^ORCID,Kostyak John C.⁴,Dulaimi Essel⁵,Chow Hoi Yee¹,Prudnikova Tatiana Y.¹,Radu Maria¹,Kunapuli Satya P.⁴,McCarty Owen J. T.³^ORCID,Chernoff Jonathan¹^ORCID

Affiliation:

1. Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA;

2. Cell and Molecular Biology, University of Pennsylvania School of Medicine, Philadelphia, PA;

3. Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR;

4. Sol Sherry Thrombosis Research Center, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA; and

5. Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA

Abstract

Key Points Bone marrow-specific deletion of Pak2 is associated with macrothrombocytopenia and abnormal megakaryocyte morphology and function. Pak2 deletion is associated with defects in megakaryocyte endomitosis and the activation of Aurora-A and LIM kinase.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/19/2995/1385453/2995.pdf

Reference66 articles.

1. Separation of megakaryocytes from mouse bone marrow by velocity sedimentation.;Nakeff;Blood,1974

2. Regulation of megakaryocytopoiesis.;Avraham;Stem Cells,1993

3. Cytoskeletal mechanics of proplatelet maturation and platelet release.;Thon;J Cell Biol,2010

4. The incredible journey: From megakaryocyte development to platelet formation.;Machlus;J Cell Biol,2013

5. Platelet bioreactor-on-a-chip.;Thon;Blood,2014

Cited by 44 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Small-Molecule Disruptors of the Interaction between Calcium- and Integrin-Binding Protein 1 and Integrin α_IIbβ₃ as Novel Antiplatelet Agents;ACS Pharmacology & Translational Science;2024-05-29

2. Modelling Takenouchi-Kosaki syndrome using disease-specific iPSCs;Stem Cell Research;2023-12

3. Inhibition of PAK1 generates an ameliorative effect on MPLW515L mouse model of myeloproliferative neoplasms by regulating the differentiation and survival of megakaryocytes;Experimental Hematology;2023-11

4. Dynamic actin/septin network in megakaryocytes co-ordinates proplatelet elaboration;Haematologica;2023-09-07

5. Novel chemical-structure TPOR agonist, TMEA, promotes megakaryocytes differentiation and thrombopoiesis via mTOR and ERK signalings;Phytomedicine;2023-02