Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor-Reference-Cited by-同舟云学术

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Published:2015-02-26 Issue:9 Volume:125 Page:1488-1496
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Puy Cristina¹²,Tucker Erik I.¹³,Matafonov Anton⁴,Cheng Qiufang⁴,Zientek Keith D.⁵,Gailani Dave⁴,Gruber András¹²³,McCarty Owen J. T.¹²⁶

Affiliation:

1. Department of Biomedical Engineering and

2. Division of Hematology and Medical Oncology, School of Medicine, Oregon Health & Science University, Portland, OR;

3. Aronora, Inc., Portland, OR;

4. Department of Pathology and Medicine, Vanderbilt University School of Medicine, Nashville, TN;

5. Research Department, Shriners Hospitals for Children, Portland, OR; and

6. Cell & Developmental Biology, School of Medicine, Oregon Health & Science University, Portland, OR

Abstract

Key Points Activated factor XI binds and proteolyzes tissue factor pathway inhibitor. Activated factor XI promotes factor X activation generation and fibrin formation through the inactivation of tissue factor pathway inhibitor from platelets and on endothelial cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/9/1488/1389190/1488.pdf

Reference33 articles.

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2. Factor XI activation in a revised model of blood coagulation.;Gailani;Science,1991

3. Factor XI contributes to thrombin generation in the absence of factor XII.;Kravtsov;Blood,2009

4. Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.;Puy;J Thromb Haemost,2013

5. Evidence for factor IX-independent roles for factor XIa in blood coagulation.;Matafonov;J Thromb Haemost,2013

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