MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

Published:2014-07-24 Issue:4 Volume:124 Page:546-554
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cui Bing¹,Chen Liguang¹,Zhang Suping¹,Mraz Marek¹²,Fecteau Jessie-F.¹,Yu Jian¹,Ghia Emanuela M.¹,Zhang Ling¹,Bao Lei¹,Rassenti Laura Z.¹,Messer Karen¹,Calin George A.³,Croce Carlo M.³,Kipps Thomas J.¹

Affiliation:

1. Moores Cancer Center, University of California, San Diego, CA;

2. Center of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; and

3. Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH, of the CLL Research Consortium

Abstract

Key Points High-level miR-155 enhances BCR signaling, and is associated with poor prognosis in CLL. Signals within the CLL microenvironment, such as CD154 or BAFF, can induce miR-155 and enhance BCR signaling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/4/546/1382462/546.pdf

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