Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma-Reference-Cited by-同舟云学术

Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma

Published:2014-09-18 Issue:12 Volume:124 Page:1915-1925
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kummetha Venkata Jagadish¹,An Ningfei¹,Stuart Robert¹,Costa Luciano J.¹,Cai Houjian²,Coker Woodrow¹,Song Jin H.³,Gibbs Kiwana⁴,Matson Terri⁵,Garrett-Mayer Elizabeth⁶,Wan Zhuang⁶,Ogretmen Besim³,Smith Charles⁷⁸,Kang Yubin¹

Affiliation:

1. Division of Hematology-Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC;

2. Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA;

3. Department of Biochemistry and Molecular Biology,

4. Hollings Cancer Center Biorepository Facility,

5. Hollings Cancer Center Clinical Trial Office,

6. Hollings Cancer Center Biostatistics, and

7. College of Pharmacy, Medical University of South Carolina, Charleston, SC; and

8. Apogee Biotechnology Corporation, Hummelstown, PA

Abstract

Key Points SK2 is overexpressed in myeloma cells and contributes to myeloma cell survival and proliferation. SK2-specific inhibitor promotes proteasome degradation of Mcl-1 and c-Myc and inhibits myeloma growth in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/12/1915/1379651/1915.pdf

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4. Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation.;Snider;Biochimie,2010

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