HOXA9 promotes hematopoietic commitment of human embryonic stem cells-Reference-Cited by-同舟云学术

HOXA9 promotes hematopoietic commitment of human embryonic stem cells

Published:2014-11-13 Issue:20 Volume:124 Page:3065-3075
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ramos-Mejía Veronica¹,Navarro-Montero Oscar¹,Ayllón Verónica¹,Bueno Clara²,Romero Tamara¹,Real Pedro J.¹,Menendez Pablo²³

Affiliation:

1. Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain;

2. Josep Carreras Leukemia Research Institute, Cell Therapy Program, School of Medicine, University of Barcelona, Barcelona, Spain; and

3. Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain

Abstract

Key Points HOXA9 parallels blood development, but is restricted to HEP, and diminishes as they differentiate into blood cells. Functional assays reveal how HOXA9 enhances blood formation by promoting commitment of HEP to CD45+ cells with higher clonogenic potential.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/20/3065/1381293/3065.pdf

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