A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance-Reference-Cited by-同舟云学术

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A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

Published:2014-09-25 Issue:13 Volume:124 Page:2061-2071
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Liu Zhiqiang¹,Xu Jingda¹,He Jin¹,Zheng Yuhuan¹,Li Haiyan¹,Lu Yong¹,Qian Jianfei¹,Lin Pei¹,Weber Donna M.¹,Yang Jing¹,Yi Qing¹

Affiliation:

1. Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Abstract

Key Points CD138+ MM cells are a major source of SHH. Autocrine SHH enhances MM drug resistance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/13/2061/1380305/2061.pdf

Reference47 articles.

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4. Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models.;Wetmore;Curr Opin Genet Dev,2003

5. Hedgehog: functions and mechanisms.;Varjosalo;Genes Dev,2008

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