Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

Author:

Torikai Hiroki1,Reik Andreas2,Soldner Frank3,Warren Edus H.4,Yuen Carrie1,Zhou Yuanyue2,Crossland Denise L.15,Huls Helen1,Littman Nicholas2,Zhang Ziying2,Tykodi Scott S.4,Kebriaei Partow6,Lee Dean A.15,Miller Jeffrey C.2,Rebar Edward J.2,Holmes Michael C.2,Jaenisch Rudolf37,Champlin Richard E.6,Gregory Philip D.2,Cooper Laurence J. N.15

Affiliation:

1. Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX;

2. Sangamo BioSciences, Inc, Richmond, CA;

3. The Whitehead Institute, Cambridge, MA;

4. Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA;

5. The University of Texas Graduate School of Biomedical Sciences and

6. Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX; and

7. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA

Abstract

Key Points Allogeneic-donor–derived cells can be genetically modified to eliminate expression of HLA-A. HLA-A disruption from donor cells is a step toward generating allogeneic cells as an off-the-shelf therapeutic.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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