CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis

Author:

Brown Ross1,Kabani Karieshma1,Favaloro James1,Yang Shihong1,Ho P. Joy1,Gibson John1,Fromm Phillip2,Suen Hayley1,Woodland Narelle3,Nassif Najah3,Hart Derek2,Joshua Douglas1

Affiliation:

1. Institute of Haematology, Royal Prince Alfred Hospital, Sydney, Australia;

2. Dendritic Cell Biology and Therapeutics, Australian and New Zealand Army Corps (ANZAC) Research Institute, Sydney, Australia; and

3. School of Medical and Molecular Biosciences, University of Technology, Sydney, Australia

Abstract

Abstract The transfer of membrane proteins between cells during contact, known as trogocytosis, can create novel cells with a unique phenotype and altered function. We demonstrate that trogocytosis is more common in multiple myeloma (MM) than chronic lymphocytic leukemia and Waldenstrom macroglobulinaemia; that T cells are more probable to be recipients than B or natural killer cells; that trogocytosis occurs independently of either the T-cell receptor or HLA compatibility; and that after trogocytosis, T cells with acquired antigens can become novel regulators of T-cell proliferation. We screened 168 patients with MM and found that CD86 and human leukocyte antigen G (HLA-G) were antigens commonly acquired by T cells from malignant plasma cells. CD3+CD86acq+ and CD3+ HLA-Gacq+ cells were more prevalent in bone marrow than peripheral blood samples. The presence of either CD86 or HLA-G on malignant plasma cells was associated with a poor prognosis. CD38++ side population cells expressed HLA-G, suggesting that these putative myeloma stem cells could generate immune tolerance. HLA-G+ T cells had a regulatory potency similar to natural Tregs, thus providing another novel mechanism for MM to avoid effective immune surveillance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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