Affiliation:
1. Department of Cardiology and Cardiovascular Diseases, Eberhard Karls Universität Tübingen, Germany
Abstract
Abstract
Besides mediating primary hemostasis and thrombosis, platelets play a critical role in tissue repair and regeneration. They regulate fundamental mechanisms involved in the healing process including cellular migration, proliferation, and angiogenesis. Control of apoptosis/cell survival and interaction with progenitor cells, which are clinically relevant but poorly understood aspects of platelets in tissue repair, will be highlighted in this review. Gaining deeper insight into the less well-characterized molecular mechanisms is necessary to develop new therapeutic platelet-based options.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Reference74 articles.
1. Platelets, inflammation and tissue regeneration.;Nurden;Thromb Haemost,2011
2. Wound repair and regeneration.;Gurtner;Nature,2008
3. Platelets in inflammation and atherogenesis.;Gawaz;J Clin Invest,2005
4. Platelets: inflammatory firebugs of vascular walls.;May;Arterioscler Thromb Vasc Biol,2008
5. Platelets in regeneration.;Stellos;Semin Thromb Hemost,2010
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