Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome

Author:

Muñiz Carmen1,Martín-Martín Lourdes1,López Antonio1,Sánchez-González Blanca2,Salar Antonio2,Almeida Julia1,Sancho Juan-Manuel3,Ribera José María3,Heras Cecilia4,Peñalver Francisco Javier5,Gómez Marta6,González-Barca Eva7,Alonso Natalia8,Navarro Belén9,Olave Teresa10,Sala Francisco11,Conde Eulogio12,Márquez José Antonio13,Cabezudo Elena14,Cladera Antonia15,García-Malo María16,Caballero María Dolores1,Orfao Alberto1

Affiliation:

1. Department of Medicine and Centro de Investigación del Cáncer (Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas/Universidad de Salamanca) and Department of Hematology, University Hospital, Instituto de Investigación Biomédica de Salamanca and University of Salamanca, Salamanca, Spain;

2. Hematology Department, Hospital del Mar, Barcelona, Spain;

3. Clinical Hematology Department, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Jose Carreras Research Institute, Badalona, Universitat Autonoma de Barcelona, Barcelona, Spain;

4. Hematology Department, Infanta Leonor Hospital, Madrid, Spain;

5. Hematology Department, University Hospital Fundación Alcorcón, Madrid, Spain;

6. Hematology Department, University Institute Parc Taulí, Sabadell, Barcelona, Spain;

7. Hematology Department, Institut Català d'Oncologia, Hospital Duran i Reynals, University of Barcelona, Institut d'Investigació Biomèdica de Bellvitge, Barcelona, Spain;

8. Hematology Department, University Hospital of Santiago, Santiago de Compostela, Spain;

9. Hematology Department, University Hospital Puerta de Hierro, Majadahonda, Madrid, Spain;

10. Hematology Department, Clinic University Hospital, Zaragoza, Spain;

11. Hematology Department, Hospital of Navarra, Pamplona, Spain;

12. Hematology Department, Marqués de Valdecilla University Hospital, Faculty of Medicine, University of Cantabria, Santander, Spain;

13. Hematology Department, Hospital Basurto, Bilbao, Spain;

14. Hematology Department, Sant Joan de Deu Hospital, Manresa, Spain;

15. Hematology Department, Hospital Son Llatzer, Mallorca, Spain; and

16. Hematology Department, Vega Baja Hospital, Orihuela, Alicante, Spain

Abstract

Key Points Increased levels of sCD19 protein in the CSF are associated with CNS disease in DLBCL and BL patients at risk of CNS lymphoma. Presence of lymphoma cells by FCM and/or increased CSF sCD19 levels are related with a poorer EFS and/or OS in DLBCL and BL patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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