Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis-Reference-Cited by-同舟云学术

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis

Published:2014-07-31 Issue:5 Volume:124 Page:791-802
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Koupenova Milka¹²³,Vitseva Olga¹,MacKay Christopher R.⁴,Beaulieu Lea M.¹,Benjamin Emelia J.²³⁵,Mick Eric⁶,Kurt-Jones Evelyn A.⁴,Ravid Katya²³⁷,Freedman Jane E.¹

Affiliation:

1. Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA;

2. Department of Medicine, and

3. Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA;

4. Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA;

5. National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Institute, Framingham, MA;

6. Division of Quantitative Health Sciences, Department of Medicine, University of Massachusetts Medical School, Worcester, MA; and

7. Evans Center for Interdisciplinary Biomedical Research, Boston University School of Medicine, Boston, MA

Abstract

Key Points Activation of platelet-TLR7 receptor mediates platelet-viral immune responses with no effect on thrombosis. This is the first study to show that platelets are necessary for survival during viral infection.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/5/791/541733/791.pdf

Reference51 articles.

1. Platelets and the immune continuum.;Semple;Nat Rev Immunol,2011

2. Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis.;Lindemann;J Cell Biol,2001

3. Protein synthesis by platelets: historical and new perspectives.;Weyrich;J Thromb Haemost,2009

4. Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance.;Wong;Nat Immunol,2013

5. Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation.;Youssefian;Blood,2002

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