Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT-Reference-Cited by-同舟云学术

Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT

Published:2014-08-07 Issue:6 Volume:124 Page:963-972
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mensen Angela¹²,Jöhrens Korinna³,Anagnostopoulos Ioannis³,Demski Sonya¹²,Oey Maike¹,Stroux Andrea⁴,Hemmati Philipp⁵,Westermann Jörg⁵,Blau Olga⁵,Wittenbecher Friedrich⁵,Movassaghi Kamran⁶,Szyska Martin²,Thomas Sybill¹,Dörken Bernd⁵,Scheibenbogen Carmen¹⁷,Arnold Renate⁵,Na Il-Kang¹²⁵

Affiliation:

1. Institute for Medical Immunology, Charité University Medicine, Berlin, Germany;

2. Experimental and Clinical Research Center, Berlin, Germany;

3. Institute of Pathology,

4. Institute for Biometry and Clinical Epidemiology,

5. Department of Hematology, Oncology and Tumor Immunology, and

6. Charité Stem Cell Facility, Charité University Medicine, Berlin, Germany; and

7. Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

Abstract

Key Points Donor T-cell infiltration of the bone marrow is associated with impaired B-cell immunity after allogeneic HSCT. Quantification of κ-deleting recombination excision circles as a biomarker for bone marrow B-cell output in different clinical episodes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/6/963/1382130/963.pdf

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5. Guidelines for preventing infectious complications among hematopoietic cell transplant recipients: a global perspective. Preface.;Tomblyn;Bone Marrow Transplant,2009

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