Corepressor Rcor1 is essential for murine erythropoiesis-Reference-Cited by-同舟云学术

Corepressor Rcor1 is essential for murine erythropoiesis

Published:2014-05-15 Issue:20 Volume:123 Page:3175-3184
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yao Huilan¹,Goldman Devorah C.²³,Nechiporuk Tamilla¹,Kawane Sunita⁴,McWeeney Shannon K.³⁴⁵,Tyner Jeffrey W.³⁶,Fan Guang⁷,Kerenyi Marc A.⁸,Orkin Stuart H.⁸⁹,Fleming William H.²³,Mandel Gail¹¹⁰

Affiliation:

1. Vollum Institute,

2. Department of Pediatrics, Oregon Stem Cell Center,

3. Knight Cancer Institute,

4. Oregon Clinical and Translational Research Institute,

5. Division of Bioinformatics and Computational Biology,

6. Department of Cell and Developmental Biology,

7. Department of Pathology, Oregon Health & Science University, Portland, OR;

8. Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA;

9. Howard Hughes Medical Institute, Boston, MA; and

10. Howard Hughes Medical Institute, Portland, OR

Abstract

Key Points Rcor1 knockout mice show a block in fetal erythropoiesis at the proerythroblast stage. Rcor1 represses expression of HSCs and myeloid genes during erythropoiesis, including Csf2rb, which is important in myeloid function.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/20/3175/1377032/3175.pdf

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