Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

Author:

Iqbal Javeed1,Wright George2,Wang Chao1,Rosenwald Andreas3,Gascoyne Randy D.4,Weisenburger Dennis D.5,Greiner Timothy C.1,Smith Lynette6,Guo Shuangping1,Wilcox Ryan A.7,Teh Bin Tean8,Lim Soon Thye8,Tan Soon Yong8,Rimsza Lisa M.9,Jaffe Elaine S.10,Campo Elias11,Martinez Antonio11,Delabie Jan12,Braziel Rita M.13,Cook James R.14,Tubbs Raymond R.14,Ott German15,Geissinger Eva3,Gaulard Philippe16,Piccaluga Pier Paolo17,Pileri Stefano A.17,Au Wing Y.18,Nakamura Shigeo19,Seto Masao19,Berger Francoise20,de Leval Laurence21,Connors Joseph M.4,Armitage James22,Vose Julie22,Chan Wing C.6,Staudt Louis M.2

Affiliation:

1. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE;

2. Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

3. Institute of Pathology, University of Würzburg, Würzburg, Germany;

4. Centre for Lymphoid Cancer, British Columbia Cancer Agency, Centre for Lymphoid Cancers, Vancouver, BC, Canada;

5. Department of Pathology, City of Hope National Medical Center, Duarte, CA;

6. Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE;

7. Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI;

8. National Cancer Center and Duke-National University of Singapore Graduate Medical School, Singapore;

9. Department of Pathology, University of Arizona, Tucson, AZ;

10. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

11. Hospital Clinic, Institut D'Investigacions Bomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain;

12. Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway;

13. Department of Clinical Pathology, Oregon Health and Science University, Portland, OR;

14. Department of Molecular Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH;

15. Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;

16. Département de Pathologie, Groupe Henri-Mondor Albert-Chenevier, Institut National de la Santé et de la Recherche Médicale U955, Université Paris Est, Créteil, France;

17. Institute of Hematology and Medical Oncology “L. and A. Seràgnoli,” S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;

18. Queen Mary Hospital, Hong Kong;

19. Aichi Cancer Center, Nagoya, Japan;

20. Centre Hospitalier Lyon-Sud, Lyon, France;

21. University Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; and

22. Department of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE

Abstract

Key Points Diagnostic signatures for PTCL subtypes and 2 novel subgroups with distinct oncogenic pathway and prognostic importance in PTCL-NOS were identified. Demonstrated that ALK(–) ALCL is a distinct molecular entity and the tumor microenvironment has prognostic significance in AITL patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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