Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia

Author:

Brown Jennifer R.1,Byrd John C.2,Coutre Steven E.3,Benson Don M.2,Flinn Ian W.4,Wagner-Johnston Nina D.5,Spurgeon Stephen E.6,Kahl Brad S.7,Bello Celeste8,Webb Heather K.9,Johnson Dave M.9,Peterman Sissy9,Li Daniel9,Jahn Thomas M.9,Lannutti Brian J.9,Ulrich Roger G.9,Yu Albert S.9,Miller Langdon L.9,Furman Richard R.10

Affiliation:

1. Dana Farber Cancer Institute, Boston, MA;

2. The Ohio State University, Columbus, OH;

3. Stanford University, Stanford, CA;

4. Sarah Cannon Research Institute, Nashville, TN;

5. Washington University, St. Louis, MO;

6. Oregon Health & Sciences University, Portland, OR;

7. University of Wisconsin, Madison, WI;

8. Moffitt Cancer Center and

9. Gilead Sciences, Inc., Seattle, WA; and

10. Weill Cornell Medical College, New York, NY

Abstract

Key Points Idelalisib was evaluated in 54 patients with heavily pretreated chronic lymphocytic leukemia, and target inhibition was documented in vivo. Oral idelalisib therapy demonstrated a favorable safety profile and rapidly induced durable disease control in the majority of patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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