A non–complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome-Reference-Cited by-同舟云学术

A non–complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome

Published:2014-05-29 Issue:22 Volume:123 Page:3478-3487
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Agostinis Chiara¹,Durigutto Paolo²,Sblattero Daniele³,Borghi Maria O.⁴⁵,Grossi Claudia⁴,Guida Filomena²,Bulla Roberta²^ORCID,Macor Paolo²,Pregnolato Francesca⁴,Meroni Pier Luigi⁴⁵,Tedesco Francesco²^ORCID

Affiliation:

1. Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico Burlo Garofolo, Trieste, Italy;

2. Department of Life Sciences, University of Trieste, Trieste, Italy;

3. Department Health Sciences and Research Institute Against Digestive Cancer, University of Eastern Piedmont, Novara, Italy;

4. Laboratory of Immuno-Rheumatology, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy; and

5. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

Abstract

Key Points A recombinant antibody recognizing the D1 domain of β2 glycoprotein I induces fetal loss and clot formation in animal models. The CH2-deleted antibody fails to activate complement and prevents the procoagulant and proabortive effects of patient antibodies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/22/3478/1378020/3478.pdf

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5. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor.;Galli;Lancet,1990

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