Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor-Reference-Cited by-同舟云学术

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

Published:2014-08-07 Issue:6 Volume:124 Page:946-954
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Xunde¹,Mendelsohn Laurel¹,Rogers Heather²,Leitman Susan³,Raghavachari Nalini⁴,Yang Yanqin¹,Yau Yu Ying³,Tallack Michael⁵,Perkins Andrew⁵,Taylor James G.¹,Noguchi Constance Tom²,Kato Gregory J.⁶^ORCID

Affiliation:

1. National Heart, Lung and Blood Institute,

2. National Institutes of Diabetes and Digestive and Kidney Diseases,

3. Clinical Center, and

4. National Institute on Aging, National Institutes of Health, Bethesda, MD;

5. Mater Medical Research Institute, Mater Hospital, Brisbane, QLD, Australia; and

6. Department of Medicine, Division of Hematology-Oncology, and the Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

Abstract

Key Points Heme-bound iron activates placenta growth factor expression in erythroid cells via EKLF, a crucial erythroid-specific transcription factor. Markers of iron burden predict mortality in adults with sickle cell disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/6/946/1382633/946.pdf

Reference67 articles.

1. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease.;Gladwin;N Engl J Med,2004

2. Mortality in adults with sickle cell disease and pulmonary hypertension.;Mehari;JAMA,2012

3. A hemodynamic study of pulmonary hypertension in sickle cell disease.;Parent;N Engl J Med,2011

4. Pulmonary hypertension diagnosed by right heart catheterisation in sickle cell disease.;Fonseca;Eur Respir J,2012

5. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.;Maglione;Proc Natl Acad Sci USA,1991

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