SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia-Reference-Cited by-同舟云学术

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

Published:2014-07-03 Issue:1 Volume:124 Page:121-133
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sasca Daniel¹,Hähnel Patricia S.¹,Szybinski Jakub¹,Khawaja Kaml¹,Kriege Oliver¹,Pante Saskia V.¹,Bullinger Lars²,Strand Susanne³,Strand Dennis³,Theobald Matthias¹,Kindler Thomas¹

Affiliation:

1. Third Department of Medicine, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Germany;

2. Department of Internal Medicine III, University of Ulm, Germany; and

3. First Department of Internal Medicine, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Germany

Abstract

Key Points SIRT1 is highly expressed in subsets of patients with acute myeloid leukemia harboring activating mutations in signaling pathways and is regulated at the protein levels. Targeting SIRT1 sensitizes leukemic blast to tyrosine kinase inhibitor treatment or chemotherapy via restoration of p53 activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/1/121/1379542/121.pdf

Reference49 articles.

1. Mammalian sirtuins: biological insights and disease relevance.;Haigis;Annu Rev Pathol,2010

2. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.;Vaquero;Nature,2007

3. Epigenetic control of rDNA loci in response to intracellular energy status.;Murayama;Cell,2008

4. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.;Oberdoerffer;Cell,2008

5. Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair.;Tamburini;Mol Cell Biol,2005

Cited by 92 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Inhibition of SIRT1 relieves hepatocarcinogenesis via alleviating autophagy and inflammation;International Journal of Biological Macromolecules;2024-10

2. Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors;Cell Reports Medicine;2024-08

3. Melatonin attenuates scopolamine‐induced cognitive dysfunction through SIRT1/IRE1α/XBP1 pathway;CNS Neuroscience & Therapeutics;2024-07

4. Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy;Leukemia;2024-06-22

5. The dual role of sirtuins in cancer: biological functions and implications;Frontiers in Oncology;2024-06-14