Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation-Reference-Cited by-同舟云学术

Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation

Published:2014-05-01 Issue:18 Volume:123 Page:2864-2872
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cardenes Nayra¹,Corey Catherine¹,Geary Lisa¹,Jain Shilpa¹²,Zharikov Sergey¹,Barge Suchitra¹,Novelli Enrico M.¹³,Shiva Sruti¹⁴

Affiliation:

1. Vascular Medicine Institute and

2. Division of Pediatric Hematology-Oncology, Children’s Hospital of Pittsburgh; and

3. Department of Medicine and

4. Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA

Abstract

Key Points Sickle cell patients show mitochondrial dysfunction (complex V inhibition, oxidant formation), which is associated with platelet activation. Complex V inhibition is induced by hemolysis and causes platelet activation, which is attenuated by mitochondrial therapeutics.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/18/2864/1377024/2864.pdf

Reference48 articles.

1. Mitochondria in the etiology and pathogenesis of Parkinson’s disease.;Schapira;Ann Neurol,1998

2. Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis.;Sjövall;Crit Care,2010

3. Quantitative study of mitochondrial complex I in platelets of parkinsonian patients.;Blandini;Mov Disord,1998

4. Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.;Shults;Ann Neurol,1997

5. Survival and mitochondrial function in septic patients according to mitochondrial DNA haplogroup.;Lorente;Crit Care,2012

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