MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia-Reference-Cited by-同舟云学术

MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia

Published:2014-07-10 Issue:2 Volume:124 Page:263-272
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Manara Elena¹,Baron Emma¹,Tregnago Claudia¹,Aveic Sanja¹,Bisio Valeria¹,Bresolin Silvia¹,Masetti Riccardo²,Locatelli Franco³,Basso Giuseppe¹,Pigazzi Martina¹

Affiliation:

1. Women and Child Health Department, Hematology-Oncology Laboratory, Instituto di Ricerca Pediatrica, University of Padova, Padova, Italy;

2. Clinica Pediatrica, Università di Bologna, Ospedale “S. Orsola,” Bologna, Italy; and

3. Oncoematologia Pediatrica, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, University of Pavia, Pavia, Italy

Abstract

Key Points MLL-AF6 leads to aberrant activation of RAS and its downstream targets. RAS targeting is a novel potential therapeutic strategy in AML patients carrying t(6;11).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/2/263/1381076/263.pdf

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