MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia

Author:

Manara Elena1,Baron Emma1,Tregnago Claudia1,Aveic Sanja1,Bisio Valeria1,Bresolin Silvia1,Masetti Riccardo2,Locatelli Franco3,Basso Giuseppe1,Pigazzi Martina1

Affiliation:

1. Women and Child Health Department, Hematology-Oncology Laboratory, Instituto di Ricerca Pediatrica, University of Padova, Padova, Italy;

2. Clinica Pediatrica, Università di Bologna, Ospedale “S. Orsola,” Bologna, Italy; and

3. Oncoematologia Pediatrica, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, University of Pavia, Pavia, Italy

Abstract

Key Points MLL-AF6 leads to aberrant activation of RAS and its downstream targets. RAS targeting is a novel potential therapeutic strategy in AML patients carrying t(6;11).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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