A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy-Reference-Cited by-同舟云学术

A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy

Published:2014-01-23 Issue:4 Volume:123 Page:471-480
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kapur Rick¹,Kustiawan Iwan²,Vestrheim Anne³⁴,Koeleman Carolien A. M.⁵,Visser Remco¹,Einarsdottir Helga K.¹,Porcelijn Leendert⁶,Jackson Dave⁷,Kumpel Belinda⁷,Deelder André M.⁵,Blank Dennis⁵,Skogen Björn⁸⁹,Killie Mette Kjaer⁸⁹,Michaelsen Terje E.³⁴,de Haas Masja¹,Rispens Theo²,van der Schoot C. Ellen¹,Wuhrer Manfred⁵,Vidarsson Gestur¹

Affiliation:

1. Department of Experimental Immunohematology and

2. Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;

3. Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Oslo, Norway;

4. School of Pharmacy, University of Oslo, Oslo, Norway;

5. Biomolecular Mass Spectrometry Unit, Leiden University Medical Center, Leiden, The Netherlands;

6. Thrombocyte and Leukocyte Serology, Sanquin, Amsterdam, The Netherlands;

7. Bristol Institute for Transfusion Sciences, National Health Service Blood and Transplant, Bristol, United Kingdom;

8. Institute of Medical Biology, University of Tromso, Tromso, Norway; and

9. University Hospital of North Norway, Tromso, Norway

Abstract

Key Points Antibodies causing FNAIT have decreased Fc fucosylation, unlike in refractory thrombocytopenia. Decreased Fc fucose increases affinity to FcγRIIIa/b, enhances platelet phagocytosis, and correlates with increased disease severity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/4/471/1378876/471.pdf

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