High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance-Reference-Cited by-同舟云学术

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

Published:2014-04-24 Issue:17 Volume:123 Page:2732-2739
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nguyen Phuong-Cac T.¹,Lewis Kenneth B.¹,Ettinger Ruth A.¹,Schuman Jason T.²,Lin Jasper C.¹,Healey John F.³,Meeks Shannon L.³,Lollar Pete³,Pratt Kathleen P.¹⁴⁵^ORCID

Affiliation:

1. Puget Sound Blood Center Research Institute, Seattle, WA;

2. GE Health Sciences, Portland, OR;

3. Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University, Atlanta, GA;

4. Division of Hematology, University of Washington, Seattle, WA; and

5. Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD

Abstract

Key Points Amino acid residues comprising B-cell epitopes recognized by neutralizing anti-factor VIII antibodies (inhibitors) have been identified. Amino acids contributing significant antigen–antibody binding avidity are candidates for mutagenesis in the design of less antigenic proteins.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/17/2732/1376462/2732.pdf

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4. Autoantibodies to coagulation factors: From pathophysiology to diagnosis and therapy.;Cugno;Autoimmun Rev,2014

5. The role of porcine factor VIII in the management of unexpected bleeding episodes.;Aledort;Haemophilia,2002

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