Distinct clustering of symptomatic burden among myeloproliferative neoplasm patients: retrospective assessment in 1470 patients

Author:

Geyer Holly L.1,Scherber Robyn M.1,Dueck Amylou C.2,Kiladjian Jean-Jacques3,Xiao Zhijian45,Slot Stefanie6,Zweegman Sonja6,Sackmann Federico7,Fuentes Ana Kerguelen8,Hernández-Maraver Dolores8,Döhner Konstanze9,Harrison Claire N.10,Radia Deepti10,Muxi Pablo11,Besses Carlos12,Cervantes Francisco13,Johansson Peter L.14,Andreasson Bjorn14,Rambaldi Alessandro15,Barbui Tiziano15,Vannucchi Alessandro M.16,Passamonti Francesco17,Samuelsson Jan18,Birgegard Gunnar19,Mesa Ruben A.20

Affiliation:

1. Division of Hospital Internal Medicine and

2. Section of Biostatistics, Mayo Clinic, Scottsdale, AZ;

3. Clinical Investigation Center, Hospital Saint-Louis, Paris, France;

4. Myelodysplastic Syndrome and Myeloproliferative Neoplasia Centre, Institute of Hematology and Blood Diseases Hospital and

5. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China;

6. Department of Hematology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands;

7. Fundaleu, Buenos Aires, Argentina;

8. Department of Haematology, University Hospital La Paz, Madrid, Spain;

9. Department of Internal Medicine III, University Hospital of Ulm, Germany;

10. Department of Haematology, Guy’s and St. Thomas National Health Service Foundation Trust, London, United Kingdom;

11. Unidadde Hematología, Hospital Británico, Montevideo, Uruguay;

12. Hematology Department, Hospital del Mar, Barcelona, Spain;

13. Hematology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Spain;

14. Internal Medicine, Nephro-Urology Hospital Organization, Uddevalla, Sweden;

15. Unit of Hematology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy;

16. Hematology Division of Hematology, Ospedale di Circolo, Varese, Italy;

17. Department of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy;

18. Department of Internal Medicine, Stockholm South Hospital, Stockholm, Sweden;

19. Department of Hematology, University Hospital, Uppsala, Sweden; and

20. Department of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ

Abstract

Key Points Distinct clusters exist within polycythemia vera, essential thrombocythemia, and myelofibrosis. Clusters are not direct surrogates for current prognostic scores.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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