miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1-Reference-Cited by-同舟云学术

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Published:2014-07-03 Issue:1 Volume:124 Page:84-95
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mraz Marek¹²³,Chen Liguang¹,Rassenti Laura Z.¹,Ghia Emanuela M.¹,Li Hongying¹,Jepsen Kristen¹,Smith Erin N.¹,Messer Karen¹,Frazer Kelly A.¹,Kipps Thomas J.¹

Affiliation:

1. University of California-San Diego, Moores Cancer Center, Department of Medicine, La Jolla, CA;

2. Central European Institute of Technology, Masaryk University, Brno, Czech Republic; and

3. Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic

Abstract

Key Points The most abundant miRNA in CLL, miR-150, is expressed at lower levels in cases with unfavorable clinicobiological markers and worse prognosis. miR-150 regulates expression of genes encoding proteins that modulate BCR signaling in CLL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/1/84/1379953/84.pdf

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