The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype-Reference-Cited by-同舟云学术

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Published:2016-12-22 Issue:25 Volume:128 Page:2960-2975
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Basiorka Ashley A.¹,McGraw Kathy L.²,Eksioglu Erika A.³,Chen Xianghong³,Johnson Joseph⁴,Zhang Ling⁵,Zhang Qing²,Irvine Brittany A.²,Cluzeau Thomas⁶⁷⁸⁹,Sallman David A.²,Padron Eric²,Komrokji Rami²,Sokol Lubomir²,Coll Rebecca C.¹⁰,Robertson Avril A. B.¹⁰,Cooper Matthew A.¹⁰,Cleveland John L.¹¹,O’Neill Luke A.¹²,Wei Sheng³,List Alan F.²

Affiliation:

1. Cancer Biology Ph.D. Program, Department of Malignant Hematology,

2. Department of Malignant Hematology,

3. Department of Immunology,

4. Analytic Microscopy Core Facility, and

5. Department of Hematopathology, H. Lee Moffitt Cancer Center, Tampa, FL;

6. Department of Hematology, Centre Hospitalier Universitaire de Nice, Nice, France;

7. Faculty of Medicine, University Nice Sophia Antipolis, Nice, France;

8. INSERM U1065, Mediterranean Center of Molecular Medicine, Nice, France;

9. French Group of Myelodysplasia, Paris, France;

10. Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia;

11. Department of Tumor Biology, H. Lee Moffitt Cancer Center, Tampa, FL; and

12. Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

Abstract

Key Points Key biological features of MDSs are explained by NLRP3 inflammasome activation, which drives pyroptotic cell death and β-catenin activation. Alarmin signals and founder gene mutations license this redox-sensitive inflammasome platform.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/25/2960/1397085/blood730556.pdf

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4. Unraveling the molecular pathophysiology of myelodysplastic syndromes;Bejar;J Clin Oncol,2011

5. Frequent pathway mutations of splicing machinery in myelodysplasia;Yoshida;Nature,2011

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